N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

Base Information

Chemical Name:N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide
CAS No.:238427-82-2
Molecular Formula:C₂₇H₃₁N₅O₃
Molecular Weight:473.575
Hs Code.:

Synonyms:N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

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Chemical Property of N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

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Technology Process of N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

There total 7 articles about N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 699-51-4
1,3-diazaspiro[4.4]nonane-2,4-dione

: 238427-82-2
N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / triphenylphosphine, diethyl azodicarboxylate / dimethylformamide / 24 h

2: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol / Ambient temperature

3: 1.) aq. HCl, NaNO₂, 2.) SnCl₂, HCl / 1.) -5-0 deg C, 30 min, 2.) RT, overnight

4: 15 percent / ethanol; H₂O / 2 h / Heating

With hydrogenchloride; hydrogen; triphenylphosphine; tin(ll) chloride; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9706325

Reference yield:

: 100-27-6
2-(4-nitrophenyl)ethanol

: 238427-82-2
N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / triphenylphosphine, diethyl azodicarboxylate / dimethylformamide / 24 h

2: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol / Ambient temperature

3: 1.) aq. HCl, NaNO₂, 2.) SnCl₂, HCl / 1.) -5-0 deg C, 30 min, 2.) RT, overnight

4: 15 percent / ethanol; H₂O / 2 h / Heating

With hydrogenchloride; hydrogen; triphenylphosphine; tin(ll) chloride; sodium nitrite; diethylazodicarboxylate; palladium on activated charcoal; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9706325

Reference yield:

: 238427-79-7
3-<2-(4-nitrophenyl)ethyl>-5-spirocyclopentanylimidazolidine-2,4-dione

: 238427-82-2
N-benzyl-3-(2-aminoethyl)-5-<2-(4-spirocyclopentanyl-2,5-dioxo-1-imidazolidinyl)ethyl>-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / H₂ / 10 percent Pd/C / ethyl acetate; ethanol / Ambient temperature

2: 1.) aq. HCl, NaNO₂, 2.) SnCl₂, HCl / 1.) -5-0 deg C, 30 min, 2.) RT, overnight

3: 15 percent / ethanol; H₂O / 2 h / Heating

With hydrogenchloride; hydrogen; tin(ll) chloride; sodium nitrite; palladium on activated charcoal; In ethanol; water; ethyl acetate;
DOI:10.1021/jm9706325