1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole

Base Information

• Chemical Name: 1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole
• CAS No.: 1254221-29-8
• Molecular Formula: C₁₆H₁₈N₂O₂Si
• Molecular Weight: 298.417
• Mol file: 1254221-29-8.mol

Synonyms:1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole

Chemical Property of 1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole

Chemical Property:

Purity/Quality:

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Technology Process of 1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole

There total 1 articles about 1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2-bromo-4-methyl-6-nitrophenyl)-1H-pyrrole (1254221-22-1) + trimethylsilylacetylene (1066-54-2) → 1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole (1254221-29-8)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 90 ℃; Inert atmosphere;

DOI:10.1021/ol102342y

Reference yield: 86.0%

1-(4-methyl-2-nitro-6-((trimethylsilyl)ethynyl)phenyl)-1H-pyrrole (1254221-29-8) → 1-(2-ethynyl-4-methyl-6-nitrophenyl)-1H-pyrrole (1254221-39-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol102342y

upstream raw materials:

1-(2-bromo-4-methyl-6-nitrophenyl)-1H-pyrrole

trimethylsilylacetylene

Downstream raw materials:

1-(2-ethynyl-4-methyl-6-nitrophenyl)-1H-pyrrole