(3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester
• CAS No.: 797789-08-3
• Molecular Formula: C₂₂H₂₉NO₃
• Molecular Weight: 355.477
• Mol file: 797789-08-3.mol

Synonyms:(3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester

Chemical Property of (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester

There total 1 articles about (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

di-tert-butyl dicarbonate (24424-99-5) + {4-[(3,5-dimethyl-benzylamino)-methyl]-phenyl}-methanol (252286-43-4) → (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (797789-08-3)

Guidance literature:

With dmap; In chloroform;

DOI:10.1021/ol048433k

Reference yield: 95.0%

3,5-dimethylphenyl isocyanate (54132-75-1) + (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (797789-08-3) → C31H38N2O4

Guidance literature:

With dibutyltin dilaurate; In chloroform; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1246/cl.151190

Reference yield: 91.0%

3,4-bis-bromomethyl-benzoyl chloride (797789-09-4) + (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (797789-08-3) → 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester (797789-10-7)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1021/ol048433k

upstream raw materials:

di-tert-butyl dicarbonate

{4-[(3,5-dimethyl-benzylamino)-methyl]-phenyl}-methanol

Downstream raw materials:

3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester

(4-chloromethyl-benzyl)-(3,5-dimethyl-benzyl)-carbamic acid tert-butyl ester

(3,5-dimethyl-benzyl)-(4-iodomethyl-benzyl)-carbamic acid tert-butyl ester

C₄₂H₅₃NO₄Si