5-(Azaniumylmethyl)-1,2-oxazol-3-olate

Base Information

Chemical Name:5-(Azaniumylmethyl)-1,2-oxazol-3-olate
CAS No.:2763-96-4
Molecular Formula:C4H6N2O2
Molecular Weight:114.104
Hs Code.:29349990
Mol file:2763-96-4.mol

Synonyms:5-(azaniumylmethyl)-1,2-oxazol-3-olate

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 5-(Azaniumylmethyl)-1,2-oxazol-3-olate

Chemical Property:

Appearance/Colour:white to off-white powder
Melting Point:175-176°C
Refractive Index:1.4487 (estimate)
Boiling Point:325°Cat760mmHg
PKA:12.19±0.40(Predicted)
Flash Point:150.4°C
PSA：72.28000
Density:1.291g/cm³
LogP:0.53920
Storage Temp.:2-8°C
Solubility.:ethanol: 1 mg/mL
Water Solubility.:Soluble in water (10 mg/ml), methanol, ethanol, 0.05 M HCl (20 mg/ml), DMSO (sparingly soluble), DMF (sparingly soluble), and PB
XLogP3:-0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:114.042927438
Heavy Atom Count:8
Complexity:78.4

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 22-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(ON=C1[O-])C[NH3+]
Description The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Benzodiazepines enhance the effects of muscimol via GABAA without altering its binding. Muscimol activates GABAC receptors with an EC50 value of 1.3 μM. It also acts as an inhibitor of GABAA uptake and a substrate for the GABA-metabolizing enzyme GABA transaminase. Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs in vivo.
Uses A potent but toxic structural analogue of g-aminobutyric acid (GABA), with a zwitterionic structure that can cross the blood-brain barrier As a molecular probe to study GABA receptors.

Technology Process of 5-(Azaniumylmethyl)-1,2-oxazol-3-olate

There total 11 articles about 5-(Azaniumylmethyl)-1,2-oxazol-3-olate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2763-95-3
5-aminomethyl-3-methoxyisoxazole hydrochloride

: 2763-96-4
muscimol

Guidance literature:: With hydrogen bromide; In acetic acid; for 0.166667h; Heating;
DOI:10.1016/S0040-4039(00)84748-6

Reference yield: 62.0%

: 2763-94-2
5-aminomethyl-3-methoxyisoxazole

: 2763-96-4
muscimol

Guidance literature:: With DOWEX W₅₀x8-200 mesh (H⁺-form); hydrogen bromide; In acetic acid; for 0.25h; Heating;
DOI:10.1080/00397919208021324