5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

Base Information

Chemical Name:5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine
CAS No.:1401732-47-5
Molecular Formula:C₂₀H₁₇ClN₄O
Molecular Weight:364.834
Hs Code.:

Synonyms:5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

There total 4 articles about 5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1111638-42-6
5-bromo-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

: 652148-92-0
2-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 1401732-47-5
5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

Reference yield:

: 62908-83-2
3-methyl-5-nitropyrazolo<3,4-b>pyridine

: 1401732-47-5
5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: palladium on activated charcoal / ethanol / 5 h / 20 °C

2.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

3.2: 0 - 20 °C / Reflux

4.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 12 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogen bromide; sodium hydride; caesium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; copper(I) bromide; In 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1186608-73-0
3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

: 1401732-47-5
5-(6-chloropyridin-2-yl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide; sodium nitrite / copper(I) bromide / water / 4 h / -5 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / -5 - 20 °C

2.2: 0 - 20 °C / Reflux

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 12 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogen bromide; sodium hydride; caesium carbonate; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) bromide; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;