5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

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Chemical Name:5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid
CAS No.:84458-81-1
Molecular Formula:C₃₁H₅₀O₃
Molecular Weight:470.736
Hs Code.:

Synonyms:5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

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Chemical Property of 5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

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Technology Process of 5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

There total 9 articles about 5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 86900-17-6
5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

: 84458-81-1
5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

Guidance literature:: With rose bengal; In ethanol; for 0.05h; Irradiation;
DOI:10.1021/jo00168a021

Reference yield: 77.0%

: 87036-80-4,87036-79-1
4-{(S)-3-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidenemethyl]-5-hydroxy-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2λ⁶-benzo[c]thiophen-1-yl}-butyric acid

: 84458-81-1
5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

: 86900-17-6
5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

Guidance literature:: With sodium hydrogencarbonate; In ethanol; at 90 - 95 ℃; for 3.5h; Title compound not separated from byproducts; sealed tube;
DOI:10.1021/jo00168a021

Reference yield:

: 67-97-0
vitamin D₃

: 84458-81-1
5-[(S)-2-[2-[(1R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-4-hydroxy-cyclohex-(E)-ylidene]-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 48 percent / liq. SO₂ / 0.5 h / Heating

2: 94 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

3: 56 percent / lithium tetramethylpiperidine / tetrahydrofuran; 1,2-dimethoxy-ethane / 1 h / -75 °C

4: 78 percent / trifluoroacetic acid / CH₂Cl₂ / 1) 0 degC, 30 min, 2) room temp., 1.5 h

5: NaHCO₃ / aq. ethanol / 3.5 h / 90 - 95 °C / sealed tube

With sulfur dioxide; 2,2,6,6-tetramethylpiperidinyl-lithium; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1021/jo00168a021