2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

Base Information

Chemical Name:2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine
CAS No.:874454-79-2
Molecular Formula:C₁₉H₁₃F₂N₅S
Molecular Weight:381.409
Hs Code.:

Synonyms:2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

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Technology Process of 2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

There total 5 articles about 2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 85118-00-9
2,6-Difluorobenzyl bromide

: 98010-52-7
C₁₂H₉N₅S

: 874454-79-2
2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

Guidance literature:: With potassium carbonate; In acetonitrile; Reflux;
DOI:10.1016/j.bmc.2012.08.059

Reference yield:

: 103-72-0
phenyl isothiocyanate

: 874454-79-2
2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 0.5 h / Reflux

2: sodium hydroxide / 0.5 h / Reflux

3: potassium carbonate / acetonitrile / Reflux

With potassium carbonate; sodium hydroxide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.08.059

Reference yield:

: 6164-79-0
methyl pyrazine-2-carboxylate

: 874454-79-2
2-(5-((2,6-difluorobenzyl)thio)-4-phenyl-4H-1,2,4-triazol-3-yl)pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / Reflux

2: ethanol / 0.5 h / Reflux

3: sodium hydroxide / 0.5 h / Reflux

4: potassium carbonate / acetonitrile / Reflux

With potassium carbonate; hydrazine hydrate; sodium hydroxide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.08.059