2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

Base Information

Chemical Name:2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal
CAS No.:609828-51-5
Molecular Formula:C₂₆H₃₈O₅
Molecular Weight:430.585
Hs Code.:

Synonyms:2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

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Chemical Property of 2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

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Technology Process of 2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

There total 19 articles about 2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{(7R,9R)-9-[(E)-(3S,4S)-4-(4-Methoxy-benzyloxy)-3,5-dimethyl-hex-1-enyl]-6,10-dioxa-spiro[4.5]dec-7-yl}-ethanol

: 609828-51-5
2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; for 0.025h;
DOI:10.1021/ja027638q

Reference yield:

: 931-94-2
1,1-dimethoxycyclopentane

: 609828-51-5
2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

Guidance literature:: Multi-step reaction with 3 steps

1: 70 mg / PPTS / CH₂Cl₂ / 2 h

2: LiAlH₄ / tetrahydrofuran / 0.75 h / -78 - 0 °C

3: 364 mg / Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.03 h

With lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja027638q

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 609828-51-5
2-(9-{(1E)(3S,4S)-4-[(4-methoxyphenyl)methoxy]-3,5-dimethylhex-1-enyl}(7S,9R)-6,10-dioxaspiro[4.5]dec-7-yl)ethanal

Guidance literature:: Multi-step reaction with 11 steps

1: 18.4 g / para-toluenesulfonic acid monohydrate / CH₂Cl₂ / 3 h

2: 98 percent / DIBAL-H / CH₂Cl₂; toluene / 0.75 h / 0 °C

3: NEt₃ / CH₂Cl₂ / 2 h / 0 °C

4: tetrahydrofuran; hexane / -20 - 20 °C

5: 400 mg / MCPBA / CH₂Cl₂ / 0 - 20 °C

6: n-BuLi; BF₃*OEt₂ / tetrahydrofuran; hexane / 1 h / -78 °C

7: 470 mg / Na₂HPO₄; Na/Hg / methanol / 1.5 h / -40 - 23 °C

8: HF*pyridine / tetrahydrofuran / 18 h

9: 70 mg / PPTS / CH₂Cl₂ / 2 h

10: LiAlH₄ / tetrahydrofuran / 0.75 h / -78 - 0 °C

11: 364 mg / Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂ / 0.03 h

With disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; boron trifluoride diethyl etherate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; sodium hydrogencarbonate; Dess-Martin periodane; toluene-4-sulfonic acid; pyridine hydrogenfluoride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
DOI:10.1021/ja027638q