tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

Base Information

Chemical Name:tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate
CAS No.:913574-83-1
Molecular Formula:C₁₉H₂₆F₂N₂O₃
Molecular Weight:368.424
Hs Code.:

Synonyms:tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

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Chemical Property of tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

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Technology Process of tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

There total 3 articles about tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 913574-82-0
tert-butyl [1-(2-oxo-3-phenylpropanoyl)piperidin-4-yl]carbamate

: 913574-83-1
tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

Guidance literature:: With diethylamino-sulfur trifluoride; In DCE; at 20 - 60 ℃; for 14h;

Reference yield:

: 69167-45-9
2-Oxo-3-phenylpropanoyl chloride

: 913574-83-1
tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h

2: diethylamino-sulfur trifluoride / DCE / 14 h / 20 - 60 °C

With diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; In DCE; dichloromethane;

Reference yield:

: 156-06-9
2-oxo-3-(phenyl)propionic acid

: 913574-83-1
tert-butyl [1-(2,2-difluoro-3-phenylpropanoyl)piperidin-4-yl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h

3: diethylamino-sulfur trifluoride / DCE / 14 h / 20 - 60 °C

With oxalyl dichloride; diethylamino-sulfur trifluoride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In DCE; dichloromethane;