(1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol

Base Information

Chemical Name:(1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol
CAS No.:110205-27-1
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:(1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol

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Chemical Property of (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol

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Technology Process of (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol

There total 2 articles about (1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 4377-41-7
2-Chloromethylquinoline

: 1-[(R)-2-Hydroxy-2-(3-hydroxy-phenyl)-ethyl]-1,3,3-trimethyl-urea

: 110205-27-1
(1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol

Guidance literature:: With caesium carbonate; In acetone; for 48h; Heating;
DOI:10.1021/jm00394a026

Reference yield:

: 61-76-7,827-62-3
phenylephrine hydrochloride

: 110205-27-1
(1R)-1-[3-[(2-quinolinyl)methoxy]phenyl]-2-(N-methyl-N-dimethylcarbamoyl)amino ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / 1 h

2: 83 percent / cesium carbonate / acetone / 48 h / Heating

With caesium carbonate; triethylamine; In tetrahydrofuran; acetone;
DOI:10.1021/jm00394a026