tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate

Base Information

• Chemical Name: tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate
• CAS No.: 119744-86-4
• Molecular Formula: C₁₄H₁₉ClN₂O₃
• Molecular Weight: 298.769
• Mol file: 119744-86-4.mol

Synonyms:tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate

Chemical Property of tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate

There total 5 articles about tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Boc-p-chloro-L-Phe-OH (51301-86-1,57292-44-1,129101-26-4,68090-88-0) → tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate (119744-86-4)

Guidance literature:

With ammonium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.bmc.2006.12.007

Reference yield: 97.0%

→ tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate (119744-86-4)

Guidance literature:

With 4-methyl-morpholine; ammonium hydroxide; methyl chloroformate; In dichloromethane; at -15 - 20 ℃;

Reference yield:

C16H20ClNO6 → tert-butyl (S)-[1-amino-3-(4-chlorophenyl)-1-oxopropan-2-yl]carbamate (119744-86-4)

Guidance literature:

With ammonium hydroxide; In dichloromethane; water;

DOI:10.1021/acs.jmedchem.0c01179

upstream raw materials:

Boc-p-chloro-L-Phe-OH

p-chlorophenylalanine

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₂H₂₉ClN₂O₅

[(S)-1-{(R)-1-[({[(S)-1-Carbamoyl-2-(4-chloro-phenyl)-ethyl]-ethyl-carbamoyl}-methyl)-carbamoyl]-4-guanidino-butylcarbamoyl}-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid tert-butyl ester

({[(S)-1-Carbamoyl-2-(4-chloro-phenyl)-ethyl]-ethyl-carbamoyl}-methyl)-carbamic acid tert-butyl ester

(S)-3-(4-Chloro-phenyl)-2-ethylamino-propionamide