2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone

Base Information

• Chemical Name: 2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone
• CAS No.: 73472-27-2
• Molecular Formula: C₂₂H₃₀O₅S₂
• Molecular Weight: 438.609
• Mol file: 73472-27-2.mol

Synonyms:2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone

Chemical Property of 2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone

There total 3 articles about 2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → 2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone (73472-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / hydrogen chloride / CHCl₃ / 0.58 h

2: 1.) n-BuLi / 1.) THF, hexane, -20 deg C, 20 min, 2.) -78 deg C, 1.5 h

With hydrogenchloride; n-butyllithium; In chloroform;

DOI:10.1021/jo00142a009

Reference yield:

2-(3,5-dimethoxy-phenyl)-1,3-dithiane (57009-72-0) + methyl (rel-2R,3S)-3-methyl-1,4-dioxaspiro[4.5]decane-2-carboxylate (73472-26-1) → 2-(3,5-dimethoxyphenyl)-m-dithian-2-yl trans-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl ketone (73472-27-2)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, -20 deg C, 20 min, 2.) -78 deg C, 1.5 h;

DOI:10.1021/jo00142a009

Reference yield:

→ [2-(3,5-Dimethoxy-phenyl)-[1,3]dithian-2-yl]-((2S,3R)-3-methyl-1,4-dioxa-spiro[4.5]dec-2-yl)-methanone (73472-27-2)

Guidance literature:

aus Verb. /BRN= 644460/ (2), Verb. /BRN= 642035/, n-BuLi/ THF;

DOI:10.1016/S0040-4039(01)95472-3

upstream raw materials:

2-(3,5-dimethoxy-phenyl)-1,3-dithiane

methyl (rel-2R,3S)-3-methyl-1,4-dioxaspiro[4.5]decane-2-carboxylate

3,5-dimethoxybenzaldehdye

Downstream raw materials:

(2R*,3R*)-α-<2-(3,5-dimethoxyphenyl)-m-dithian-2-yl>-3-methyl-1,4-dioxaspiro<4.5>decane-2-methanol

(2R*,3R*)-α-<(3,5-dimethoxy-2,5-cyclohexadien-1-yl)-methyl>-3-methyl-1,4-dioxaspiro<4.5>decane-2-methanol

5-<2-hydroxy-2-<(2R*,3R*)-3-methyl-1,4-dioxaspiro<4.5>-dec-2-yl>ethyl>-3-methoxy-2-cyclohexen-1-one

5-<2-(tert-butyldimethylsiloxy)-2-<(2R*,3S*)-3-methyl-1,4-dioxaspiro<4.5>dec-2-yl>ethyl>-3-methoxy-2-cyclohexen-1-one