Technology Process of (3R,4S,5S)-3-amino-5-(4-amino-3-fluoro-5-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)benzyl)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide
There total 11 articles about (3R,4S,5S)-3-amino-5-(4-amino-3-fluoro-5-((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)benzyl)-4-hydroxytetrahydro-2H-thiopyran 1,1-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; ammonia; hydrogen;
In
methanol;
at 25 ℃;
for 50h;
Inert atmosphere;
DOI:10.1021/jm300069y
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 2 h / 25 °C / Inert atmosphere
2: palladium 10% on activated carbon; ammonia; hydrogen / methanol / 50 h / 25 °C / Inert atmosphere
With
hydrogenchloride; palladium 10% on activated carbon; ammonia; hydrogen;
In
tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm300069y
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: thionyl chloride / 0 - 25 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 4 h / 0 - 5 °C / Inert atmosphere
2.2: 0.5 h / 25 °C / Cooling with ice; Inert atmosphere
3.1: phosphorus tribromide / 24 h / 25 °C / Inert atmosphere
4.1: potassium carbonate / acetone / 2.5 h / 25 - 30 °C / Inert atmosphere
5.1: palladium diacetate; triethylamine; triphenylphosphine / tert-butyl methyl ether / 16 h / 25 °C / Inert atmosphere
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -70 °C / Inert atmosphere
7.1: Chiralpak AD-I / ethanol; n-heptane / Inert atmosphere
8.1: potassium hexamethylsilazane / tetrahydrofuran / 24 h / 25 °C / Inert atmosphere
9.1: potassium peroxymonosulfate / tetrahydrofuran; water / 2 h / 25 °C / Inert atmosphere
10.1: hydrogenchloride / tetrahydrofuran; 1,4-dioxane / 2 h / 25 °C / Inert atmosphere
11.1: palladium 10% on activated carbon; ammonia; hydrogen / methanol / 50 h / 25 °C / Inert atmosphere
With
hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; potassium peroxymonosulfate; palladium 10% on activated carbon; ammonia; hydrogen; palladium diacetate; phosphorus tribromide; potassium hexamethylsilazane; diisobutylaluminium hydride; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; n-heptane; tert-butyl methyl ether; water; acetone;
DOI:10.1021/jm300069y
