[1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal

Base Information

• Chemical Name: [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal
• CAS No.: 766549-75-1
• Molecular Formula: C₁₅H₁₄N₂O₃
• Molecular Weight: 270.288

Synonyms:[1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal

Chemical Property of [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal

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Technology Process of [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal

There total 3 articles about [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-(3-hydroxy-prop-1-ynyl)-1-(4-methoxy-benzyl)-3-methyl-1,3-dihydro-imidazol-2-one (766549-74-0) → [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal (766549-75-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane;

DOI:10.1016/j.tetlet.2004.07.062

Reference yield:

5-[3-(tert-butyl-dimethyl-silanyloxy)-prop-1-ynyl]-1-methyl-1,3-dihydro-imidazol-2-one (766549-73-9) → [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal (766549-75-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / KOtBu / dimethylformamide

2: 99 percent / TBAF / tetrahydrofuran

3: 77 percent / barium manganate / CHCl₃

With barium manganate; potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.07.062

Reference yield:

4-[3-(tert-butyl-dimethyl-silanyloxy)-prop-1-ynyl]-1-(4-methoxy-benzyl)-3-methyl-1,3-dihydro-imidazol-2-one (766549-79-5) → [1-(4-methoxy-benzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl]-propynal (766549-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / TBAF / tetrahydrofuran

2: 77 percent / barium manganate / CHCl₃

With barium manganate; tetrabutyl ammonium fluoride; In tetrahydrofuran; chloroform;

DOI:10.1016/j.tetlet.2004.07.062

upstream raw materials:

4-(3-hydroxy-prop-1-ynyl)-1-(4-methoxy-benzyl)-3-methyl-1,3-dihydro-imidazol-2-one

5-[3-(tert-butyl-dimethyl-silanyloxy)-prop-1-ynyl]-1-methyl-1,3-dihydro-imidazol-2-one

4-[3-(tert-butyl-dimethyl-silanyloxy)-prop-1-ynyl]-1-(4-methoxy-benzyl)-3-methyl-1,3-dihydro-imidazol-2-one

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