3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

Base Information

Chemical Name:3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester
CAS No.:959801-07-1
Molecular Formula:C₂₈H₂₄Cl₃N₃O₃
Molecular Weight:556.876
Hs Code.:

Synonyms:3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

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Chemical Property of 3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

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Technology Process of 3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

There total 12 articles about 3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959801-05-9
2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-benzaldehyde

: 959801-07-1
3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

Guidance literature:: 3-(diethoxy-phosphorylmethyl)-benzoic acid methyl ester; With sodium hydride; In diethyl ether; at 0 ℃; for 1h;

2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-benzaldehyde; In diethyl ether;

Reference yield:

: 57341-09-0
1-azido-2,6-dichlorobenzene

: 959801-07-1
3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: neat (no solvent) / 100 °C

2: diisobutylaluminium hydride / tetrahydrofuran

3: di-isopropyl azodicarboxylate / dichloromethane

With di-isopropyl azodicarboxylate; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2014.11.050

Reference yield:

: 56962-11-9
2-chloro-4-hydroxybenzaldehyde

: 959801-07-1
3-(2-{2-chloro-4-[3-(2,6-dichloro-phenyl)-5-isopropyl-3H-[1,2,3]triazol-4-ylmethoxy]-phenyl}-vinyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1H-imidazole / N,N-dimethyl-formamide

2: sodium hydride / tetrahydrofuran / 0 - 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran

4: di-isopropyl azodicarboxylate / dichloromethane

With 1H-imidazole; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: |Horner-Wadsworth-Emmons Olefination - Still-Gennari Modification / 4: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2014.11.050