C₂₂H₂₀BrNO₂

Base Information

Chemical Name:C₂₂H₂₀BrNO₂
CAS No.:1447766-83-7
Molecular Formula:C₂₂H₂₀BrNO₂
Molecular Weight:410.31
Hs Code.:

C<sub>22</sub>H<sub>20</sub>BrNO<sub>2</sub>

Synonyms:C₂₂H₂₀BrNO₂

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Chemical Property of C₂₂H₂₀BrNO₂

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Technology Process of C₂₂H₂₀BrNO₂

There total 1 articles about C₂₂H₂₀BrNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: C₂₂H₂₂BrNO₂

: 1447766-83-7
C₂₂H₂₀BrNO₂

Guidance literature:: C₂₂H₂₂BrNO₂; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 1h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/ja405548b

Reference yield: 36.0%

: 1447766-83-7
C₂₂H₂₀BrNO₂

: 195372-72-6
(S)-2-methyl-2,3,4,5-tetrahydropyridine 1-oxide

: 1447766-82-6
C₂₈H₃₁BrN₂O₃

: 1447766-89-3
C₂₈H₃₁BrN₂O₃

Guidance literature:: With L-proline; In dichloromethane; acetonitrile; for 216h; stereoselective reaction; Inert atmosphere;
DOI:10.1021/ja405548b

Reference yield:

: 1447766-83-7
C₂₂H₂₀BrNO₂

: 1447766-81-5
C₂₉H₃₃BrN₂O₂

Guidance literature:: Multi-step reaction with 5 steps

1.1: L-proline / dichloromethane; acetonitrile / 216 h / Inert atmosphere

2.1: sodium hydride / mineral oil; dimethyl sulfoxide / 0.75 h / Inert atmosphere

2.2: 30 h / 20 °C / Inert atmosphere

3.1: sodium iodide; chloro-trimethyl-silane / tetrahydrofuran; acetonitrile / 2 h / Inert atmosphere

4.1: acetic acid; zinc / tetrahydrofuran / 25 h / 20 °C / Inert atmosphere

5.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1.33 h / Inert atmosphere

5.2: 15 h / 20 °C / Inert atmosphere

With chloro-trimethyl-silane; sodium hydride; acetic acid; methanesulfonyl chloride; triethylamine; L-proline; sodium iodide; zinc; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetonitrile; mineral oil;
DOI:10.1021/ja405548b