[(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester
CAS No.:1434723-14-4
Molecular Formula:C₁₄H₁₉ClFNO₃
Molecular Weight:303.761
Hs Code.:

Synonyms:[(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

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Technology Process of [(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

There total 11 articles about [(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1434722-50-5
(R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-amide

: 1434723-14-4
[(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: (R)-2-methyl-propane-2-sulfinic acid [(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-amide; With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃; for 1h;

di-tert-butyl dicarbonate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1434722-54-9
acetic acid 6-chloro-2-fluoro-3-methyl-phenyl ester

: 1434723-14-4
[(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 80 °C / Inert atmosphere

2.1: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

3.1: sodium hydroxide / methanol / 1 h / 50 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

5.1: titanium(IV) tetraethanolate / dichloromethane / 20 °C / Inert atmosphere

6.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

7.1: cesium fluoride / acetonitrile; water / 20 °C

8.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

8.2: 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; titanium(IV) tetraethanolate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver nitrate; cesium fluoride; sodium hydroxide; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1434722-60-7
acetic acid 6-chloro-3-dibromomethyl-2-fluoro-phenyl ester

: 1434723-14-4
[(R)-1-(4-chloro-2-fluoro-3-hydroxy-phenyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: silver nitrate / isopropyl alcohol; water / 1 h / 32 °C

2.1: sodium hydroxide / methanol / 1 h / 50 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: titanium(IV) tetraethanolate / dichloromethane / 20 °C / Inert atmosphere

5.1: tetrahydrofuran; diethyl ether / 3 h / -78 °C / Inert atmosphere

6.1: cesium fluoride / acetonitrile; water / 20 °C

7.1: hydrogenchloride / methanol; ethyl acetate / 1 h / 20 °C

7.2: 2 h / 20 °C

With 1H-imidazole; hydrogenchloride; titanium(IV) tetraethanolate; silver nitrate; cesium fluoride; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;