N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Base Information

• Chemical Name: N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
• CAS No.: 1586020-01-0
• Molecular Formula: C₅₁H₈₁N₁₁O₇S
• Molecular Weight: 992.34
• Mol file: 1586020-01-0.mol

Synonyms:N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Chemical Property of N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide

There total 10 articles about N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]biotinamide (875770-34-6) + 2-cyclohexyl-N-(1-(hex-5-yn-1-yl)piperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine (1586014-83-6) → N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (1586020-01-0)

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; In dichloromethane; at 20 ℃;

DOI:10.1002/cmdc.201300450

Reference yield:

methyl 4-(3-chloropropoxy)-3-methoxybenzoate (111627-40-8) → N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (1586020-01-0)

Guidance literature:

Multi-step reaction with 7 steps

1: nitric acid; acetic anhydride / 0 - 20 °C

2: potassium carbonate; sodium iodide; tetra-(n-butyl)ammonium iodide / acetonitrile / Reflux

3: iron; ammonium acetate / ethyl acetate; water / Reflux

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: N,N-diethylaniline; trichlorophosphate / Reflux

6: potassium carbonate / N,N-dimethyl-formamide / 60 °C

7: tetrakis(actonitrile)copper(I) hexafluorophosphate / dichloromethane / 20 °C

With hydrogenchloride; tetrakis(actonitrile)copper(I) hexafluorophosphate; ammonium acetate; nitric acid; acetic anhydride; tetra-(n-butyl)ammonium iodide; iron; potassium carbonate; N,N-diethylaniline; sodium iodide; trichlorophosphate; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/cmdc.201300450

Reference yield:

tert-butyl (1-(hex-5-yn-1-yl)piperidin-4-yl)carbamate → N-(2-(2-(2-(2-(4-(4-(4-((2-cyclohexyl-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-yl)amino)piperidin-1-yl)butyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide (1586020-01-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 6 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 60 °C

3: tetrakis(actonitrile)copper(I) hexafluorophosphate / dichloromethane / 20 °C

With tetrakis(actonitrile)copper(I) hexafluorophosphate; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201300450

upstream raw materials:

methyl 4-(3-chloropropoxy)-3-methoxybenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

5-hexynyl p-toluenesulfonate

N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]biotinamide