tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

Base Information

Chemical Name:tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane
CAS No.:193622-68-3
Molecular Formula:C₁₅H₂₇IOSi
Molecular Weight:378.369
Hs Code.:

Synonyms:tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

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Chemical Property of tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

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Technology Process of tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

There total 6 articles about tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 193622-67-2
tert-Butyl-{(1S,2S)-3-[1-iodo-eth-(Z)-ylidene]-2-iodomethyl-cyclohexyloxy}-dimethyl-silane

: 193622-68-3
tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 48h; Ambient temperature;
DOI:10.1021/jo970605m

Reference yield:

: 29329-03-1
5-hexynal

: 193622-68-3
tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 52 percent / tetrahydrofuran / 12 h / -78 - 20 °C

3: 98 percent / imidazole / dimethylformamide / 12 h

4: 1.) n-BuLi / 1) THF, hexane, -78 deg C, 1 h; 2) THF, hexane, rt, 7 h

5: 1.) n-BuLi, Cp₂TiCl₂, 2.) N-iodosuccinimide / 1) hexane, THF, -55 deg C --> rt, rt, 7 h; 2) hexane, THF, Ch₂Cl₂, -50 deg C, 1 h, rt, 1 h

6: 70 percent / DBU / CH₂Cl₂ / 48 h / Ambient temperature

With 1H-imidazole; bis(cyclopentadienyl)titanium dichloride; N-iodo-succinimide; n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970605m

Reference yield:

: 66927-76-2
(±)-oct-1-en-7-yn-3-ol

: 193622-68-3
tert-Butyl-{(S)-3-[1-iodo-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

2: 98 percent / imidazole / dimethylformamide / 12 h

3: 1.) n-BuLi / 1) THF, hexane, -78 deg C, 1 h; 2) THF, hexane, rt, 7 h

4: 1.) n-BuLi, Cp₂TiCl₂, 2.) N-iodosuccinimide / 1) hexane, THF, -55 deg C --> rt, rt, 7 h; 2) hexane, THF, Ch₂Cl₂, -50 deg C, 1 h, rt, 1 h

5: 70 percent / DBU / CH₂Cl₂ / 48 h / Ambient temperature

With 1H-imidazole; bis(cyclopentadienyl)titanium dichloride; N-iodo-succinimide; n-butyllithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo970605m