6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

Base Information

Chemical Name:6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline
CAS No.:422566-51-6
Molecular Formula:C₄₂H₃₉NO₈
Molecular Weight:685.774
Hs Code.:

Synonyms:6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

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Chemical Property of 6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

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Technology Process of 6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

There total 2 articles about 6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 190278-33-2
4-Benzyloxy-5-methoxy-2-methoxymethoxy-benzoic acid methyl ester

: 6-benzyloxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline

: 422566-51-6
6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

Guidance literature:: 6-benzyloxy-7-methoxy-1-(3-methoxy-benzyl)-isoquinoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -10 ℃; for 1h;

4-Benzyloxy-5-methoxy-2-methoxymethoxy-benzoic acid methyl ester; In tetrahydrofuran; hexane; at -10 ℃; for 1h;
DOI:10.1021/np0104525

Reference yield:

: 67370-95-0
methyl 4-benzyloxy-2-hydroxy-5-methoxybenzoate

: 422566-51-6
6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran

2.1: LDA / tetrahydrofuran; hexane / 1 h / -10 °C

2.2: 19 percent / tetrahydrofuran; hexane / 1 h / -10 °C

With sodium hydride; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/np0104525

Reference yield:

: 422566-51-6
6-benzyloxy-7-methoxy-1-[1-(3-methoxyphenyl)-2-(4-benzyloxy-5-methoxy-2-methoxymethoxyphenyl)-2-oxoethyl]isoquinoline

: 3,10-dihydroxy-2,11-dimethoxy-13-(3-methoxy-phenyl)-5-oxa-6b-aza-dibenzo[a,i]fluoren-6-one

Guidance literature:: Multi-step reaction with 4 steps

1: 22 h / 70 °C

2: aq. HCl / methanol / 0.5 h / Heating

3: Et₃N / methanol / 2 h / Heating

4: 72 percent / H₂ / 20 percent Pd(OHO)2/C / ethyl acetate / 8 h / 20 °C / 760 Torr

With hydrogenchloride; hydrogen; triethylamine; palladium hydroxide - carbon; In methanol; ethyl acetate;
DOI:10.1021/np0104525