((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

Base Information

Chemical Name:((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester
CAS No.:1599453-99-2
Molecular Formula:C₃₄H₃₉FN₄O₅
Molecular Weight:602.706
Hs Code.:

((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

Synonyms:((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

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Chemical Property of ((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

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Technology Process of ((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

There total 6 articles about ((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2900-27-8
(2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid

: 1599453-99-2
((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine; trifluoro-[1,3,5]triazine / dichloromethane / 2 h / 23 °C

2: 2,6-di-tert-butyl-pyridine / dichloromethane / 20 °C

3: hydrogenchloride / water; 1,4-dioxane / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

5: lithium hydroxide; methanol / tetrahydrofuran; water / 2.5 h / 23 °C

6: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 1.33 h / 0 - 23 °C

With pyridine; hydrogenchloride; methanol; trifluoro-[1,3,5]triazine; 2,6-di-tert-butyl-pyridine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate;

Reference yield:

: 261951-69-3
(5-fluoro-2-methylphenyl)methanamine

: 1599453-98-1
(S)-1-{(S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-2-phenylacetyl}-2,3-dihydro-1H-indole-2-carboxylic acid

: 1599453-99-2
((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; ethyl acetate; at 0 - 23 ℃; for 1.33h;

Reference yield:

: 1599453-96-9
(S)-1-((S)-2-amino-2-phenylacetyl)-2,3-dihydro-1H-indole-2-carboxylic acid ethyl ester hydrochloride

: 1599453-99-2
((S)-1-{(S)-2-[(S)-2-(5-fluoro-2-methylbenzylcarbamoyl)-2,3-dihydroindol-1-yl]-2-oxo-1-phenylethylcarbamoyl}ethyl)methylcarbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 20 °C

2: lithium hydroxide; methanol / tetrahydrofuran; water / 2.5 h / 23 °C

3: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; ethyl acetate / 1.33 h / 0 - 23 °C

With methanol; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;