methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

Base Information

Chemical Name:methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate
CAS No.:76116-46-6
Molecular Formula:C₁₅H₂₁N₂O₈P
Molecular Weight:388.314
Hs Code.:

Synonyms:methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

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Chemical Property of methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

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Technology Process of methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

There total 4 articles about methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 84673-38-1
methyl-3,3-bis(trimethylsilyl)phosphono-3-<(N-benzyloxycarbonyl-D,L-alanyl)amino>-propanoate

: 76116-46-6
methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

Guidance literature:: With water; In acetone; for 3h;
DOI:10.1016/0040-4020(82)85087-4

Reference yield:

: 76116-61-5
methyl-3,3-dimethylphosphono-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-propanoate

: 76116-46-6
methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

Guidance literature:: With trimethylsilyl bromide;
DOI:10.1039/c39800000730

Reference yield:

: 4132-86-9,26607-51-2,1142-20-7
N-benzyloxycarbonylalanine

: 76116-46-6
methyl-3-<(N-benzyloxycarbonyl-D,L-alanyl)-amino>-3-phosphonopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / triethylamine, isobutyl chloroformate / CH₂Cl₂ / 0.67 h / -20 °C

2: 15 percent / HCl / 13.5 h / 0 - 25 °C

3: 94 percent / CH₂Cl₂ / 3 h

4: 80 percent / water / acetone / 3 h

With hydrogenchloride; water; triethylamine; isobutyl chloroformate; In dichloromethane; acetone;
DOI:10.1016/0040-4020(82)85087-4