VPC₉₆₁₁₅

Base Information

• Chemical Name: VPC₉₆₁₁₅
• CAS No.: 1266665-51-3
• Molecular Formula: C₂₄H₃₉N₃O*ClH
• Molecular Weight: 422.054
• Mol file: 1266665-51-3.mol

Synonyms:VPC₉₆₁₁₅

Chemical Property of VPC₉₆₁₁₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of VPC₉₆₁₁₅

There total 5 articles about VPC₉₆₁₁₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(R)-1-(4-dodecylbenzoyl)pyrrolidine-2-carbonitrile (1266666-45-8) → VPC96115 (1266665-51-3)

Guidance literature:

(R)-1-(4-dodecylbenzoyl)pyrrolidine-2-carbonitrile; With sodium methylate; In methanol; at 20 - 50 ℃; for 24h; Inert atmosphere;

With ammonium chloride; In methanol; at 50 ℃; Inert atmosphere;

DOI:10.1021/jm2001053

Reference yield: 26.0%

→ VPC96115 (1266665-51-3)

Guidance literature:

Reference yield:

(2R)-pyrrolidine-2-carbonitrile (TFA salt) → VPC96115 (1266665-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

2.2: 50 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;

DOI:10.1021/jm2001053

upstream raw materials:

(R)-1-(4-dodecylbenzoyl)pyrrolidine-2-carbonitrile

(R)-2-carbamoylpyrrolidine-1-carboxylic acid tert-butyl ester

(R)-2-cyanopyrrolidine-1-carboxylic acid tert-butyl ester

Refernces

• 1、 Kennedy, Andrew J.,Mathews, Thomas P.,Kharel, Yugesh,Field, Saundra D.,Moyer, Morgan L.,East, James E.,Houck, Joseph D.,Lynch, Kevin R.,MacDonald, Timothy L.. "Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells". . p. 3524 - 3548. Retrieved 2011/07/07.