(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester
CAS No.:1056678-84-2
Molecular Formula:C₃₄H₅₀FN₃O₆
Molecular Weight:615.786
Hs Code.:

(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

Synonyms:(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

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Chemical Property of (S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

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Technology Process of (S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

There total 8 articles about (S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1056678-67-1
(2S,3S)-2-amino-3-methyl-pentanoic acid 4-fluoro-benzylamide

: 1056676-05-1
[(S)-2-benzyloxy-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-carbamic acid tert-butyl ester

: 1056678-84-2
(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

Guidance literature:: With 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine; at 70 ℃; for 96h;

Reference yield:

: 906662-73-5
(4S,1'S)-4-(1-hydroxy-3-methoxycarbonylprop-2-ynyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 1056678-84-2
(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: hydrogen / palladium on activated charcoal / ethyl acetate / 3 h

2: acetic acid / toluene / 4 - 5 h / Heating / reflux

3: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes; tripyrrolidine phosphorus oxide / 4.5 h / -78 - 20 °C

4: water; trifluoroacetic acid / 1 h / 20 °C

5: sodium carbonate / 1,4-dioxane; water / 2 h / 20 °C

6: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

7: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / 96 h / 70 °C

With 2-hydroxypyridin; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; water; hydrogen; sodium carbonate; acetic acid; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; tripyrrolidine phosphorus oxide; water; ethyl acetate; toluene;

Reference yield:

: 906662-77-9
(4S,2'S)-2,2-dimethyl-4-(5-oxotetrahydrofuran-2-yl)oxazolidine-3-carboxylic acid tert-butyl ester

: 1056678-84-2
(S)-{(2S,4S)-1-benzyloxymethyl-4-[(1S,2S)-1-(4-fluoro-benzylcarbamoyl)-2-methyl-butylcarbamoyl]-2-hydroxy-5-methyl-hexyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexanes; tripyrrolidine phosphorus oxide / 4.5 h / -78 - 20 °C

2: water; trifluoroacetic acid / 1 h / 20 °C

3: sodium carbonate / 1,4-dioxane; water / 2 h / 20 °C

4: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 20 °C

5: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / 96 h / 70 °C

With 2-hydroxypyridin; n-butyllithium; trimethylsilyl trifluoromethanesulfonate; water; sodium carbonate; diisopropylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; tripyrrolidine phosphorus oxide; water;