(+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane

Base Information

• Chemical Name: (+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane
• CAS No.: 370884-70-1
• Molecular Formula: C₂₁H₂₂F₃NO₃
• Molecular Weight: 393.406

Synonyms:(+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane

Chemical Property of (+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane

There total 2 articles about (+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

hydrocinnamic acid chloride (645-45-4) + (+/-)-N-trifluoroacetyl-1-(2-methoxyphenyl)-2-aminopropane (370884-68-7) → (+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane (370884-70-1)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jm0100739

Reference yield:

(d,l)-2-methoxyamphetamine (15402-84-3,117772-42-6,73495-53-1) → (+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane (370884-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / benzene / 2 h / Heating

2: 24 percent / TiCl₄ / CH₂Cl₂ / 72 h / 20 °C

With titanium tetrachloride; In dichloromethane; benzene; 2: Friedel-Crafts reaction;

DOI:10.1021/jm0100739

Reference yield: 99.0%

(+/-)-N-trifluoroacetyl-1-[2-methoxy-5-(3-phenyl-1-propionyl)phenyl]-2-aminopropane (370884-70-1) → 2,2,2-trifluoro-N-{2-[2-methoxy-5-(3-phenyl-propyl)-phenyl]-1-methyl-ethyl}-acetamide

Guidance literature:

With hydrogen; acetic acid; 10percent Pd/C; at 20 ℃; for 5.5h; under 2327.23 Torr;

DOI:10.1021/jm0100739

upstream raw materials:

hydrocinnamic acid chloride

(+/-)-N-trifluoroacetyl-1-(2-methoxyphenyl)-2-aminopropane

(d,l)-2-methoxyamphetamine

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