Technology Process of 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid
There total 5 articles about 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid methyl ester;
With
lithium hydroxide monohydrate; water;
In
tetrahydrofuran;
at 20 ℃;
for 20h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
Cooling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 60 °C
1.2: 2 h / 0 - 95 °C
2.1: caesium carbonate; butyl-1-adamantylphosphine / palladium diacetate / toluene; water / 20 h / 100 °C / Inert atmosphere
3.1: potassium carbonate; CyJohnPhos / palladium diacetate / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere; Reflux
4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 h / 20 °C
4.2: Cooling
With
lithium hydroxide monohydrate; butyl-1-adamantylphosphine; water; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; CyJohnPhos;
palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate; CyJohnPhos / palladium diacetate / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere; Reflux
2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 h / 20 °C
2.2: Cooling
With
lithium hydroxide monohydrate; water; potassium carbonate; CyJohnPhos;
palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane;
