5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

Base Information

Chemical Name:5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid
CAS No.:1415898-29-1
Molecular Formula:C₁₅H₁₂Cl₂N₂O₂
Molecular Weight:323.178
Hs Code.:

Synonyms:5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

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Chemical Property of 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

Chemical Property:

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Technology Process of 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

There total 5 articles about 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1415898-28-0
5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid methyl ester

: 1415898-29-1
5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

Guidance literature:: 5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid methyl ester; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 20h;

With hydrogenchloride; In tetrahydrofuran; water; Cooling;

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 1415898-29-1
5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 h / 60 °C

1.2: 2 h / 0 - 95 °C

2.1: caesium carbonate; butyl-1-adamantylphosphine / palladium diacetate / toluene; water / 20 h / 100 °C / Inert atmosphere

3.1: potassium carbonate; CyJohnPhos / palladium diacetate / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere; Reflux

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 h / 20 °C

4.2: Cooling

With lithium hydroxide monohydrate; butyl-1-adamantylphosphine; water; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; CyJohnPhos; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;

Reference yield:

: 1415898-27-9
methyl 6-chloro-5-cyclopropyl-pyridine-2-carboxylate

: 1415898-29-1
5-cyclopropyl-6-(2,4-dichloro-phenylamino)-pyridine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate; CyJohnPhos / palladium diacetate / 1,4-dioxane / 20 h / 20 °C / Inert atmosphere; Reflux

2.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 20 h / 20 °C

2.2: Cooling

With lithium hydroxide monohydrate; water; potassium carbonate; CyJohnPhos; palladium diacetate; In tetrahydrofuran; 1,4-dioxane;