methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

Base Information

Chemical Name:methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate
CAS No.:591217-68-4
Molecular Formula:C₂₅H₂₆N₂O₅
Molecular Weight:434.492
Hs Code.:

Synonyms:methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

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Chemical Property of methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

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Technology Process of methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

There total 1 articles about methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.6%

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 516465-99-9
6-[(tert-butoxycarbonyl)-amino]-2-naphthoic acid

: 591217-68-4
methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; (3aR,4R,7S,7aS)-2-hydroxy-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione (N-hydroxy-5-exo-norbornene-2,3-dicarboximide); In N,N-dimethyl-formamide; at 20 ℃; for 7h;
DOI:10.1016/j.bmc.2004.06.020

Reference yield: 96.0%

: 591217-68-4
methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

: 591217-69-5
4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;
DOI:10.1016/j.bmc.2004.06.020

Reference yield:

: 591217-68-4
methyl 4-[({6-[(tert-butoxycarbonyl)amino]-2-naphthoyl}amino)methyl]benzoate

: 6-amino-naphthalene-2-carboxylic acid 4-hydroxycarbamoyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. LiOH / tetrahydrofuran

2: BOP-Cl; TEA / CH₂Cl₂

3: H₂ / 10 percent Pd/C / methanol

4: methanolic HCl

With hydrogenchloride; lithium hydroxide; TEA; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(02)00175-0