<2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester

Base Information

• Chemical Name: <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester
• CAS No.: 107967-06-6
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.406
• Mol file: 107967-06-6.mol

Synonyms:<2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester

Chemical Property of <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester

There total 5 articles about <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester (107967-05-5) → <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester (107967-06-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 0.666667h; under 2068.6 Torr;

DOI:10.1021/jo00308a013

Reference yield:

dimethyl 2-(4-methoxybenzylidene)malonate (7443-25-6) → <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester (107967-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / Ambient temperature

2: SnCl₂*2H₂O, conc. HCl / methanol / 4.5 h

With hydrogenchloride; sodium hydride; tin(ll) chloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00082a020

Reference yield:

1-methyl-2-nitrobenzene (88-72-2) → <2-(2-aminophenyl)-1-(4-methoxyphenyl)ethyl>propanedioic acid, dimethyl ester (107967-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / NaH / dimethylformamide / Ambient temperature

2: 91 percent / H₂ / 10percent Pd/C / methanol / 1.) RT, 30 min, 2.) 50-55 deg C, 1 h

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00082a018

upstream raw materials:

[1-(4-Methoxyphenyl)-2-(2-nitrophenyl)ethyl]-propanedioic acid,dimethyl ester

1-methyl-2-nitrobenzene

dimethyl 2-(4-methoxybenzylidene)malonate

Downstream raw materials:

cis-3-(acetyloxy)-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride

cis-3-hydroxy-1-<2-(dimethylamino)ethyl>-1,3,4,5-tetrahydro-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one, monohydrochloride

1,3,4,5-tetrahydro-3-hydroxy-3-(methoxycarbonyl)-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

cis-1,3,4,5-tetrahydro-3-hydroxy-4-(methoxyphenyl)-2H-1-benzazepin-2-one