1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Base Information

Chemical Name:1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane
CAS No.:938462-79-4
Molecular Formula:C₁₅H₂₁NO
Molecular Weight:231.338
Hs Code.:

Synonyms:1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Suppliers and Price of 1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

There total 5 articles about 1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 938463-23-1
1S,5R-(+)-2-benzyl-5-(3-methoxyphenyl)-2-aza-bicyclo[3.3.1]nonane

: 938462-79-4
1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 6h; under 3102.97 Torr;
DOI:10.1039/b618875c

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 938462-79-4
1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-BuLi / tetrahydrofuran / 2 h / -60 °C

1.2: tetrahydrofuran / 2 h / 20 °C

2.1: 51.4 g / p-toluenesulfonic acid monohydrate / toluene / 6 h / Heating

3.1: sec-BuLi / cyclohexane; tetrahydrofuran / 1 h / -40 °C

3.2: cyclohexane; tetrahydrofuran / 2 h / 0 °C

4.1: aq. H₃PO₄; formic acid / 72 h / 20 °C

5.1: 35.2 g / NaBH₄ / methanol / 2 h / 20 °C

6.1: (+)-di-O,O'-p-toluyl-D-tartaric acid / acetone / 0.33 h

6.2: NH₄OH

7.1: 93 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C / 3102.97 Torr

With sodium tetrahydroborate; n-butyllithium; (2S,3S)-di-4-toluoyltartaric acid; hydrogen; sec.-butyllithium; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; formic acid; cyclohexane; phosphoric acid; acetone; toluene;
DOI:10.1039/b618875c

Reference yield:

: 1026869-17-9
C₂₂H₂₅NO

: 938462-79-4
1S,5R-(-)-5-(3-methoxyphenyl)-2-aza-bicyclo-[3.1.1]nonane

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. H₃PO₄; formic acid / 72 h / 20 °C

2.1: 35.2 g / NaBH₄ / methanol / 2 h / 20 °C

3.1: (+)-di-O,O'-p-toluyl-D-tartaric acid / acetone / 0.33 h

3.2: NH₄OH

4.1: 93 percent / hydrogen / Pd/C / methanol / 6 h / 20 °C / 3102.97 Torr

With sodium tetrahydroborate; (2S,3S)-di-4-toluoyltartaric acid; hydrogen; palladium on activated charcoal; In methanol; formic acid; phosphoric acid; acetone;
DOI:10.1039/b618875c