(1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane

Base Information

• Chemical Name: (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane
• CAS No.: 62349-01-3
• Molecular Formula: C₃₇H₄₂O₁₂S₄
• Molecular Weight: 806.997
• Mol file: 62349-01-3.mol

Synonyms:(1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane

Chemical Property of (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane

There total 5 articles about (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

p-toluenesulfonyl chloride (98-59-9) + (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(hydroxymethyl)cyclopentane (150617-83-7) → (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane (62349-01-3) + (1RS,2RS,4SR,5SR)-2,4-bis(((tolyl-4-sylfonyl)oxy)methyl)-7-oxabicyclo[3.3.0]octane

Guidance literature:

With pyridine; at -20 ℃; for 5h;

DOI:10.1021/jo001146j

Reference yield: 5.0%

p-toluenesulfonyl chloride (98-59-9) + (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(hydroxymethyl)cyclopentane (150617-83-7) → (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane (62349-01-3)

Guidance literature:

With pyridine; at 25 ℃; for 19h;

Reference yield:

(1RS,7SR,8SR,10RS)-8,10-bis(hydroxymethyl)-4,4-dimethyl-3,5-dioxabicyclo[5.3.0]decane (333380-84-0) → (1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(((tolyl-4-sylfonyl)oxy)methyl)cyclopentane (62349-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / water; Amberlite IR-120(H) / tetrahydrofuran / 2 h / 65 °C

2: 65 percent / pyridine / 5 h / -20 °C

With pyridine; Amberlite IR-120(H); water; In tetrahydrofuran;

DOI:10.1021/jo001146j

upstream raw materials:

p-toluenesulfonyl chloride

(1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis(hydroxymethyl)cyclopentane

(1RS,7SR,8SR,10RS)-8,10-bis(hydroxymethyl)-4,4-dimethyl-3,5-dioxabicyclo[5.3.0]decane

cis,cis,cis,cis-1,2,3,4-cyclopentanetetracarboxylic acid

Downstream raw materials:

(1RS,2RS,3SR,4SR)-1,2,3,4-tetrakis((diphenylphosphanyl)methyl)cyclopentane