5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Base Information

Chemical Name:5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride
CAS No.:74245-69-5
Molecular Formula:C₂₉H₃₄N₂O₆*ClH
Molecular Weight:543.06
Hs Code.:

Synonyms:5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

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Chemical Property of 5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

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Technology Process of 5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

There total 7 articles about 5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73642-19-0
5-acetoxy-8-hydroxy-3,4-dihydrocarbostyril

: 74245-69-5
5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / conc. H₂SO₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 83.8 percent / K₂CO₃ / methanol / 1 h / Heating

3: 2.) HCl / 1.) methanol, 4 h, reflux, 2.) acetone

With hydrogenchloride; sulfuric acid; potassium carbonate; In methanol; dichloromethane;
DOI:10.1248/cpb.29.2166

Reference yield:

: 79784-54-6
5-hydroxy-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril

: 74245-69-5,79784-49-9
(R)(+)-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / dimethylformamide / 9.5 h / 60 - 65 °C

2: 3.5N KOH / methanol / 1 h / Ambient temperature

3: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

With piperidine; hydrogenchloride; potassium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.29.2157

Reference yield:

: 61306-76-1
5,8-diacetoxy-3,4-dihydrocarbostyril

: 74245-69-5
5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-8-hydroxy-3,4-dihydrocarbostyril hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 67.8 percent / AcONa*3H₂O, carbon / methanol / 0.83 h / Heating

2: 78 percent / conc. H₂SO₄ / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 83.8 percent / K₂CO₃ / methanol / 1 h / Heating

4: 2.) HCl / 1.) methanol, 4 h, reflux, 2.) acetone

With hydrogenchloride; sulfuric acid; sodium acetate; potassium carbonate; pyrographite; In methanol; dichloromethane;
DOI:10.1248/cpb.29.2166