Technology Process of 3-(4-fluorophenyl)-2-[(4-methoxyphenyl)sulfinyl]-1-benzofuran
There total 5 articles about 3-(4-fluorophenyl)-2-[(4-methoxyphenyl)sulfinyl]-1-benzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 0 ℃;
for 0.5h;
Sealed tube;
DOI:10.1039/c8ob02680g
- Guidance literature:
-
2-[(4-methoxyphenyl)sulfinyl]-1-benzofuran;
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex;
In
tetrahydrofuran;
at -30 ℃;
for 0.333333h;
Inert atmosphere;
4-fluoro-1-iodobenzene;
With
tetrakis(triphenylphosphine) palladium(0); zinc(II) chloride;
In
tetrahydrofuran;
at 25 ℃;
for 1h;
Inert atmosphere;
DOI:10.1039/b907330b
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide / dichloromethane / 1 h / 50 °C / Sealed tube
2: tetrakis(triphenylphosphine) palladium(0); sodium carbonate; lithium chloride / toluene; ethanol; water / 3 h / Sealed tube; Reflux; Inert atmosphere
3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Sealed tube
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); sodium carbonate; 3-chloro-benzenecarboperoxoic acid; lithium chloride;
In
ethanol; dichloromethane; water; toluene;
2: |Suzuki Coupling;
DOI:10.1039/c8ob02680g
