4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

Base Information

Chemical Name:4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide
CAS No.:365572-28-7
Molecular Formula:C₂₄H₃₂BrNO₄
Molecular Weight:478.426
Hs Code.:

Synonyms:4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

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Chemical Property of 4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

Chemical Property:

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Technology Process of 4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

There total 10 articles about 4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyryl chloride

: 365572-28-7
4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

Guidance literature:: With ammonia; In tetrahydrofuran; for 2h;
DOI:10.3390/70400374

Reference yield:

: 40141-12-6
1-(Chloromethyl)-4-(1-methylethoxy)benzene

: 365572-28-7
4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

2: KOH / ethanol; H₂O / 12 h / Heating

3: 13.3 g / 0.5 h / 160 °C / 0 Torr

4: oxalyl chloride / CH₂Cl₂ / 2 h / 0 °C

5: 19.9 g / ammonia / tetrahydrofuran / 2 h

With potassium hydroxide; oxalyl dichloride; ammonia; potassium carbonate; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3390/70400374

Reference yield:

: 365572-22-1
2-bromo-4-methoxy-5-(1-methylethoxy)benzeneacetaldehyde

: 365572-28-7
4-(2-bromo-5-isopropoxy-4-methoxy-phenyl)-2-(4-isopropoxy-benzyl)-butyramide

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / sodium borohydride / ethanol / 2 h / 15 °C

2: 77 percent / imidazole; iodine; triphenylphosphine / CH₂Cl₂ / 2 h / 20 °C

3: 72 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

4: 91 percent / potassium carbonate / dimethylformamide / 12 h / 80 °C

5: KOH / ethanol; H₂O / 12 h / Heating

6: 13.3 g / 0.5 h / 160 °C / 0 Torr

7: oxalyl chloride / CH₂Cl₂ / 2 h / 0 °C

8: 19.9 g / ammonia / tetrahydrofuran / 2 h

With 1H-imidazole; potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; ammonia; iodine; potassium carbonate; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.3390/70400374