8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

Base Information

Chemical Name:8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride
CAS No.:114054-80-7
Molecular Formula:C₁₇H₂₀N₄O₃*ClH
Molecular Weight:364.832
Hs Code.:

Synonyms:8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

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Chemical Property of 8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

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Technology Process of 8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

There total 3 articles about 8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 114020-88-1
4-(3-Chloropropyl)amino-5-p-ethoxyphenylcarbamoyl-2-hydroxy-6-methylpyrimidine hydrochloride

: 114054-80-7
8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

Guidance literature:: In tetrahydrofuran; at 60 ℃; for 10h;

Reference yield:

: 114020-77-8
2-Hydroxy-4-(3-hydroxy-propylamino)-6-methyl-pyrimidine-5-carboxylic acid (4-ethoxy-phenyl)-amide

: 114054-80-7
8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / SOCl₂ / CHCl₃ / 5 h / 50 °C

2: 83 percent / tetrahydrofuran / 10 h / 60 °C

With thionyl chloride; In tetrahydrofuran; chloroform;

Reference yield:

: 114020-89-2
6-methyl-2-oxo-4-thioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 4-ethoxy-anilide

: 114054-80-7
8-Methyl-6-oxo-1,3,4,6-tetrahydro-2H-pyrimido[1,6-a]pyrimidine-9-carboxylic acid (4-ethoxy-phenyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / pyridine / 4 h / Heating

2: 68 percent / SOCl₂ / CHCl₃ / 5 h / 50 °C

3: 83 percent / tetrahydrofuran / 10 h / 60 °C

With thionyl chloride; In tetrahydrofuran; pyridine; chloroform;