[3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

Base Information

Chemical Name:[3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester
CAS No.:168909-67-9
Molecular Formula:C₁₅H₂₅ClNO₃P
Molecular Weight:333.795
Hs Code.:

Synonyms:[3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

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Chemical Property of [3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

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Technology Process of [3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

There total 6 articles about [3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 133457-75-7
ethyl (2-carboxamido-2-(4-chlorophenyl)-2-hydroxyethyl)n-butylphosphinate

: 168909-67-9
[3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; for 3h; Heating;
DOI:10.1021/jm00017a016

Reference yield:

: 21661-52-9
ethyl butylphosphinate

: 168909-67-9
[3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / tetrahydrofuran / 24 h / Ambient temperature

2: 62 percent / ZnCl₂ / tetrahydrofuran / 6 h / Heating

3: 89 percent / gaseous NH₃, NaCN / ethanol / 10 h / 50 °C

4: 40 percent / BH₃*Me₂S / tetrahydrofuran / 3 h / Heating

With dimethylsulfide borane complex; sodium cyanide; ammonia; triethylamine; zinc(II) chloride; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00017a016

Reference yield:

: 101492-44-8
ethyl 2-(4-chlorophenyl)acrylate

: 168909-67-9
[3-Amino-2-(4-chloro-phenyl)-2-hydroxy-propyl]-butyl-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / m-chloroperbenzoic acid / CHCl₃ / 24 h / Heating

2: 62 percent / ZnCl₂ / tetrahydrofuran / 6 h / Heating

3: 89 percent / gaseous NH₃, NaCN / ethanol / 10 h / 50 °C

4: 40 percent / BH₃*Me₂S / tetrahydrofuran / 3 h / Heating

With dimethylsulfide borane complex; sodium cyanide; ammonia; 3-chloro-benzenecarboperoxoic acid; zinc(II) chloride; In tetrahydrofuran; ethanol; chloroform;
DOI:10.1021/jm00017a016