Technology Process of 1-(4-cyanophenyl)-4-oxa-7-phenylhepta-1,6-diyne
There total 3 articles about 1-(4-cyanophenyl)-4-oxa-7-phenylhepta-1,6-diyne which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; potassium carbonate; triphenylphosphine;
palladium on activated charcoal;
In
1,2-dimethoxyethane; water;
at 70 ℃;
for 7h;
DOI:10.1021/ja066485u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: K2CO3; CuI; PPh3 / Pd/C / 1,2-dimethoxy-ethane; H2O / 7 h / 70 °C
2.1: NaH / dimethylformamide / 1 h / 0 °C
2.2: dimethylformamide / 14 h / 20 °C
3.1: K2CO3; CuI; PPh3 / Pd/C / 1,2-dimethoxy-ethane; H2O / 7 h / 70 °C
With
copper(l) iodide; sodium hydride; potassium carbonate; triphenylphosphine;
palladium on activated charcoal;
In
1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
1.1: Sonogashira coupling / 2.2: Williamson etherification / 3.1: Sonogashira coupling;
DOI:10.1021/ja066485u
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NaH / dimethylformamide / 1 h / 0 °C
1.2: dimethylformamide / 14 h / 20 °C
2.1: K2CO3; CuI; PPh3 / Pd/C / 1,2-dimethoxy-ethane; H2O / 7 h / 70 °C
With
copper(l) iodide; sodium hydride; potassium carbonate; triphenylphosphine;
palladium on activated charcoal;
In
1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
1.2: Williamson etherification / 2.1: Sonogashira coupling;
DOI:10.1021/ja066485u
