tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate
CAS No.:1349877-56-0
Molecular Formula:C₂₇H₃₁ClIN₅O₃
Molecular Weight:635.932
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

There total 14 articles about tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₂₅Cl₂IN₄O₃

: 62-53-3
aniline

: 1349877-56-0
tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In toluene; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2011.10.015

Reference yield:

: C₂₁H₂₈ClIN₄O₄

: 62-53-3
aniline

: 1349877-56-0
tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

Guidance literature:: C₂₁H₂₈ClIN₄O₄; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h;

aniline; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; toluene; at 20 ℃; for 12h;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 309956-78-3,172603-05-3
(R)-piperidin-3-ylcarbamic acid tert-butyl ester

: 1349877-56-0
tert-butyl {(3R)-1-[1-(2-chlorobenzyl)-4-iodo-5-(phenylcarbamoyl)-1H-imidazol-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropyl alcohol / 2.5 h / 20 °C

1.2: 6 h / 0 - 80 °C

2.1: potassium carbonate / acetonitrile / 72 h / 40 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 15 °C

4.1: diiodomethane; isopentyl nitrite / toluene / 9 h / 80 °C

5.1: sodium hydroxide / ethanol / 6 h / 80 °C

6.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 20 °C

With oxalyl dichloride; diiodomethane; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; isopentyl nitrite; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; mineral oil; 4.1: Sandmeyer reaction;
DOI:10.1016/j.tet.2011.10.015