Technology Process of 2-[4-(4-Fluoro-benzoyl)-phenoxy]-2-methyl-propionic acid isopropyl ester
There total 3 articles about 2-[4-(4-Fluoro-benzoyl)-phenoxy]-2-methyl-propionic acid isopropyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C21H22O6;
With
tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; copper(II) bis(trifluoromethanesulfonate);
In
acetonitrile;
at 23 ℃;
for 0.5h;
Sealed tube;
Inert atmosphere;
In
acetonitrile;
at 35 ℃;
for 6h;
Irradiation;
Sealed tube;
Inert atmosphere;
DOI:10.1021/jacs.1c02490
- Guidance literature:
-
Multi-step reaction with 2 steps
1: acetylhydroxamic acid; potassium carbonate / dimethyl sulfoxide / 40 h / 80 °C / Sealed tube
2: tetramethylammonium fluoride; fluorosulfonyl fluoride / N,N-dimethyl-formamide / 24 h / 25 °C / Inert atmosphere; Glovebox; Sealed tube
With
fluorosulfonyl fluoride; acetylhydroxamic acid; tetramethylammonium fluoride; potassium carbonate;
In
dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jacs.6b12911
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ruthenium trichloride; sodium periodate / water; ethyl acetate / 15 h / 70 °C
2.1: copper(II) bis(trifluoromethanesulfonate); tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride / acetonitrile / 0.5 h / 23 °C / Sealed tube; Inert atmosphere
2.2: 6 h / 35 °C / Irradiation; Sealed tube; Inert atmosphere
With
ruthenium trichloride; sodium periodate; tetrakis(acetonitrile)copper(I)tetrafluoroborate; tetrabutylammonium tetra(tert-butyl alcohol) coordinate fluoride; copper(II) bis(trifluoromethanesulfonate);
In
water; ethyl acetate; acetonitrile;
DOI:10.1021/jacs.1c02490
