(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate
CAS No.:1246221-03-3
Molecular Formula:C₁₄H₁₇F₃N₄O₂
Molecular Weight:330.31
Hs Code.:

Synonyms:(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

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Technology Process of (R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

There total 7 articles about (R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 486460-00-8,922178-94-7
(3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid

: 1246221-03-3
(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Guidance literature:: With dipotassium peroxodisulfate; 4-toluenesulfonyl azide; silver nitrate; In water; acetonitrile; at 60 ℃; for 6h;

Reference yield:

: 1246221-01-1
C₁₅H₂₀F₃NO₅S

: 1246221-03-3
(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 67 ℃; for 18h;
DOI:10.1002/cmdc.201300104

Reference yield:

: 1500076-05-0
(Z)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)acrylate

: 1246221-03-3
(R)-tert-butyl (1-azido-3-(2,4,5-trifluorophenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,2-bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen / methanol / 18 h / 3750.38 Torr / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 2 h / 0 - 20 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

4: sodium azide / N,N-dimethyl-formamide / 18 h / 67 °C

With lithium borohydride; sodium azide; 1,2-bis[(2R,5R)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201300104