Technology Process of Boc-Hse(Bn)-Thr-OMe
There total 1 articles about Boc-Hse(Bn)-Thr-OMe which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
L-threonine methyl ester hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 18 ℃;
for 0.5h;
(S)-2-((tert-butoxy)carbonylamino)-4-(phenylmethoxy)butyric acid;
With
diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 18 ℃;
for 16h;
DOI:10.1080/10610278.2012.688128
- Guidance literature:
-
With
(bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
dichloromethane;
at -20 - 20 ℃;
for 7h;
Inert atmosphere;
DOI:10.1080/10610278.2012.688128
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 7 h / -20 - 20 °C / Inert atmosphere
2.1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 6 h / -20 - 20 °C
3.1: water; sodium hydroxide / methanol / 2 h / 20 °C
3.2: pH 5
4.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 16 h / 20 °C
5.1: dichloromethane / 2 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 20 °C
7.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere
8.1: trimethylamine hydrochloride; triethylamine / acetonitrile / 3 h / 0 °C
With
Bromotrichloromethane; palladium 10% on activated carbon; water; hydrogen; trimethylamine hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1080/10610278.2012.688128
