Technology Process of 1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene
There total 2 articles about 1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium methoxide / methanol / 0.5 h / -40 °C
2: 85 percent / triethylamine / methanol; toluene / 1 h / 20 °C
3: 88 percent / Pd2(dibenzylideneacetone)3; triethylamine; triphenylphosphine / dimethylformamide / 3 h / 60 °C
With
tris-(dibenzylideneacetone)dipalladium(0); sodium methylate; triethylamine; triphenylphosphine;
In
methanol; N,N-dimethyl-formamide; toluene;
3: Sonogashira reaction;
DOI:10.1139/v02-053
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 85 percent / triethylamine / methanol; toluene / 1 h / 20 °C
2: 88 percent / Pd2(dibenzylideneacetone)3; triethylamine; triphenylphosphine / dimethylformamide / 3 h / 60 °C
With
tris-(dibenzylideneacetone)dipalladium(0); triethylamine; triphenylphosphine;
In
methanol; N,N-dimethyl-formamide; toluene;
2: Sonogashira reaction;
DOI:10.1139/v02-053
- Guidance literature:
-
With
sodium methylate;
In
methanol;
at 25 ℃;
for 4h;
DOI:10.1139/v02-053
