1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene

Base Information

Chemical Name:1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene
CAS No.:494848-87-2
Molecular Formula:C₅₂H₆₄N₂O₂₄S₂
Molecular Weight:1165.21
Hs Code.:

Synonyms:1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene

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Chemical Property of 1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene

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Technology Process of 1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene

There total 2 articles about 1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104556-69-6
2-Thiosialic acid methyl ester peracetate

: 494848-87-2
1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methoxide / methanol / 0.5 h / -40 °C

2: 85 percent / triethylamine / methanol; toluene / 1 h / 20 °C

3: 88 percent / Pd₂(dibenzylideneacetone)3; triethylamine; triphenylphosphine / dimethylformamide / 3 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium methylate; triethylamine; triphenylphosphine; In methanol; N,N-dimethyl-formamide; toluene; 3: Sonogashira reaction;
DOI:10.1139/v02-053

Reference yield:

: 112702-00-8
5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-2-nonulopyranosidonate

: 494848-87-2
1,4-bis-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylthioonate prop-2-ynyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / triethylamine / methanol; toluene / 1 h / 20 °C

2: 88 percent / Pd₂(dibenzylideneacetone)3; triethylamine; triphenylphosphine / dimethylformamide / 3 h / 60 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; triphenylphosphine; In methanol; N,N-dimethyl-formamide; toluene; 2: Sonogashira reaction;
DOI:10.1139/v02-053