1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:1426695-17-1
Molecular Formula:C₂₁H₂₆ClFN₆O
Molecular Weight:432.928
Hs Code.:

Synonyms:1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of 1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of 1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 8 articles about 1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865451-01-0
1-(5-chloro-4-fluoro-2-hydroxyphenyl)ethan-1-one

: 1426695-17-1
1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-iodo-succinimide / acetic acid / 2 h / 70 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

3.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

5.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

6.2: 35 °C

7.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

8.1: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; N-iodo-succinimide; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; potassium carbonate; ethylene dibromide; triethylamine; N,N-dimethyl-formamide; zinc; In 1,4-dioxane; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1382996-83-9
1-(5-chloro-4-fluoro-3-iodo-2-methoxyphenyl)ethanone

: 1426695-17-1
1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: zinc; chloro-trimethyl-silane; ethylene dibromide / N,N-dimethyl-formamide / 1 h / 40 °C

1.2: 70 °C

2.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

3.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

4.2: 35 °C

5.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; chloro-trimethyl-silane; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; ethylene dibromide; triethylamine; N,N-dimethyl-formamide; zinc; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1382996-84-0
tert-butyl 3-(3-acetyl-5-chloro-6-fluoro-2-methoxyphenyl)azetidine-1-carboxylate

: 1426695-17-1
1-{1-[5-chloro-4-fluoro-3-(1-isopropylazetidin-3-yl)-2-methoxyphenyl]ethyl}-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

2.1: 1,3,5-trichloro-2,4,6-triazine; N,N-dimethyl-formamide / dichloromethane / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C

3.2: 35 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; 1,3,5-trichloro-2,4,6-triazine; sodium hydride; triethylamine; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;