2-methyl-5-nitrophenyl triflate

Base Information

• Chemical Name: 2-methyl-5-nitrophenyl triflate
• CAS No.: 1195931-65-7
• Molecular Formula: C₈H₆F₃NO₅S
• Molecular Weight: 285.201
• Mol file: 1195931-65-7.mol

Synonyms:2-methyl-5-nitrophenyl triflate

Chemical Property of 2-methyl-5-nitrophenyl triflate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-5-nitrophenyl triflate

There total 1 articles about 2-methyl-5-nitrophenyl triflate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + 2-methyl-5-nitrophenol (5428-54-6) → 2-methyl-5-nitrophenyl triflate (1195931-65-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c01116

Reference yield: 83.0%

2-methyl-5-nitrophenyl triflate (1195931-65-7) → 2-fluoro-4-nitrotoluene (1427-07-2)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; t-BuBrettPhos; cesium fluoride; In toluene; at 110 ℃; for 12h;

DOI:10.1126/science.1178239

Reference yield:

2-methyl-5-nitrophenyl triflate (1195931-65-7) + m-Anisidine (536-90-3,918666-97-4) → C14H14N2O3

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01116

upstream raw materials:

trifluoromethylsulfonic anhydride

2-methyl-5-nitrophenol

Downstream raw materials:

2-fluoro-4-nitrotoluene