(1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

Base Information

Chemical Name:(1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate
CAS No.:154704-06-0
Molecular Formula:C₂₂H₃₄N₄O₆S
Molecular Weight:482.601
Hs Code.:

(1S,2S)-tert-Butyl 1-<N-(tert-butoxycarbonyl)amino>-2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

Synonyms:(1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

Chemical Property:

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Technology Process of (1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

There total 5 articles about (1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 154704-05-9
(1S,2S)-tert-Butyl 1--2-<<<(methylthio)(toluenesulfonylimido)methyl>amino>methyl>cyclopropane-1-carboxylate

: 154704-06-0
(1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

Guidance literature:: With ammonia; silver nitrate; In acetonitrile; at 25 ℃; for 3h; Yield given;
DOI:10.1021/jo00087a039

Reference yield:

: 154704-03-7
(1S,2R)-1-tert-Butoxycarbonylamino-2-methanesulfonyloxymethyl-cyclopropanecarboxylic acid tert-butyl ester

: 154704-06-0
(1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaN₃ / dimethylformamide / 15 h / 60 °C

2: H₂ / 10percent Pd/C / methanol / 12 h / 25 °C

3: xylene / 5 h / Heating

4: NH₃, AgNO₃ / acetonitrile / 3 h / 25 °C

With sodium azide; ammonia; hydrogen; silver nitrate; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetonitrile; xylene;
DOI:10.1021/jo00087a039

Reference yield:

: 154704-04-8
(1S,2S)-tert-Butyl 2-(azidomethyl)-1-cyclopropane-1-carboxylate

: 154704-06-0
(1S,2S)-tert-Butyl 1--2-<<2-(4-methylbenzenesulfonyl)guanidino>methyl>cyclopropane-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / methanol / 12 h / 25 °C

2: xylene / 5 h / Heating

3: NH₃, AgNO₃ / acetonitrile / 3 h / 25 °C

With ammonia; hydrogen; silver nitrate; palladium on activated charcoal; In methanol; acetonitrile; xylene;
DOI:10.1021/jo00087a039