(R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

Base Information

Chemical Name:(R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid
CAS No.:1214265-67-4
Molecular Formula:C₂₆H₃₀N₆O₅
Molecular Weight:506.561
Hs Code.:

Synonyms:(R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

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Chemical Property of (R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

Chemical Property:

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Technology Process of (R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

There total 4 articles about (R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035204-54-6
(R)-ethyl-3-chloro-5-cyclopentyl-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridine-7-carboxylate

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 1214265-67-4
(R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at 90 ℃; for 20h;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 1214265-67-4
(R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride; diethyl chlorophosphate

1.2: -78 - 20 °C

2.1: hydrogenchloride / isopropyl alcohol / 95 °C

With hydrogenchloride; sodium hydride; diethyl chlorophosphate; In isopropyl alcohol;
DOI:10.1016/j.bmcl.2016.10.009

Reference yield:

: 755039-54-4
(R)-2-chloro-8-cyclopentyl-7-ethyl-7,8-dihydropteridin-6(5H)-one

: 1214265-67-4
(R)-4-(5-cyclopentyl-7-(ethoxycarbonyl)-6-ethyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-3-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride; diethyl chlorophosphate

1.2: -78 - 20 °C

2.1: hydrogenchloride / isopropyl alcohol / 95 °C

With hydrogenchloride; sodium hydride; diethyl chlorophosphate; In isopropyl alcohol;
DOI:10.1016/j.bmcl.2016.10.009