(S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

Base Information

Chemical Name:(S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate
CAS No.:1632153-84-4
Molecular Formula:C₂₃H₃₁N₃O₈
Molecular Weight:477.514
Hs Code.:

Synonyms:(S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

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Chemical Property of (S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

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Technology Process of (S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

There total 4 articles about (S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1632153-79-7
(S)-benzyl ((3,6-dioxopiperazin-2-yl)methyl)carbamate

: 1632153-84-4
(S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

Guidance literature:: With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1055/s-0033-1340622

Reference yield:

: 1653959-67-1
Boc-Dap(Z)-Gly-OEt

: 1632153-84-4
(S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1 h / 20 °C

2: acetic acid; 4-methyl-morpholine / butan-1-ol / 1 h / 150 °C / Microwave irradiation

3: dmap / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; acetic acid; In dichloromethane; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1055/s-0033-1340622

Reference yield:

: 1653959-81-9
C₁₅H₂₁N₃O₅*C₂HF₃O₂

: 1632153-84-4
(S)-di-tert-butyl 3-((((benzyloxy)carbonyl)amino)methyl)-2,5-dioxopiperazine-1,4-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; 4-methyl-morpholine / butan-1-ol / 1 h / 150 °C / Microwave irradiation

2: dmap / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With 4-methyl-morpholine; dmap; acetic acid; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1055/s-0033-1340622