(5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

Base Information

Chemical Name:(5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone
CAS No.:1381883-51-7
Molecular Formula:C₂₉H₂₄ClN₃O₂
Molecular Weight:481.981
Hs Code.:

Synonyms:(5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

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Chemical Property of (5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

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Technology Process of (5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

There total 3 articles about (5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 3222-47-7
6-methylnicotinic acid

: 1381883-26-6
C₂₂H₁₉ClN₂O

: 1381883-51-7
(5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 8h; Reflux;
DOI:10.1016/j.bmc.2012.04.047

Reference yield: 69.0%

: 1381883-51-7
(5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

Guidance literature:: With hydrazine hydrate; In propan-1-ol; at 90 ℃; for 10h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 45 ℃; for 12h;

Reference yield:

: 86711-44-6
C₂₂H₁₇ClO₂

: 1381883-51-7
(5-(4-(benzyloxy)phenyl)-3-(4-chlorophenyl)-4,5-dihydro-1H-pyrazol-1-yl)(6-methylpyridin-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / isopropyl alcohol / 8 h / Reflux

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8 h / Reflux

With benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.04.047