3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

Base Information

Chemical Name:3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide
CAS No.:1232836-37-1
Molecular Formula:C₂₀H₂₁F₃IN₃O
Molecular Weight:503.306
Hs Code.:

Synonyms:3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

Chemical Property:

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Technology Process of 3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

There total 6 articles about 3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89976-12-5
1-methyl-4-nitro-2-(trifluoromethyl) benzene

: 1232836-37-1
3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 24 h / Reflux; Inert atmosphere

2: triethylamine / 3 h / 20 °C

3: iron; ammonium chloride / water; ethanol / 1 h / Reflux

4: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

5: hydrogenchloride / methanol

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); iron; ammonium chloride; triethylamine; In methanol; tetrachloromethane; ethanol; dichloromethane; water;

Reference yield:

: 694499-22-4
1-(bromomethyl)-4-nitro-2-(trifluoromethyl) benzene

: 1232836-37-1
3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / 3 h / 20 °C

2: iron; ammonium chloride / water; ethanol / 1 h / Reflux

3: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

4: hydrogenchloride / methanol

With hydrogenchloride; iron; ammonium chloride; triethylamine; In methanol; ethanol; dichloromethane; water;

Reference yield:

: 859027-32-0
4-(4-nitro-2-trifluoromethyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

: 1232836-37-1
3-iodo-4-methyl-N-[4-(piperazin-1-ylmethyl)-3-(trifluoromethyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: iron; ammonium chloride / water; ethanol / 1 h / Reflux

2: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

3: hydrogenchloride / methanol

With hydrogenchloride; iron; ammonium chloride; triethylamine; In methanol; ethanol; dichloromethane; water;