(R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline

Base Information

• Chemical Name: (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline
• CAS No.: 897026-57-2
• Molecular Formula: C₂₉H₃₀ClN₅O₄
• Molecular Weight: 548.041

Synonyms:(R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline

Chemical Property of (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline

Chemical Property:

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Technology Process of (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline

There total 1 articles about (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

4-[5-(2-ethyl-2H-tetrazolyl)]phenol (859538-91-3) + (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-hydroxypropyl)-Δ2-isoxazoline (897026-56-1) → (R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ2-isoxazoline (897026-57-2)

Guidance literature:

With diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield: 73.0%

(R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ2-isoxazoline (897026-57-2) → (R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ2-isoxazoline (897026-58-3)

Guidance literature:

With hydrogen; palladium(II) hydroxide/carbon; In ethanol;

upstream raw materials:

4-[5-(2-ethyl-2H-tetrazolyl)]phenol

(R/S)-3-(5-benzyloxy-3-chloro-2-methoxyphenyl)-5-(3-hydroxypropyl)-Δ²-isoxazoline

Downstream raw materials:

(R/S)-3-(3-chloro-5-hydroxy-2-methoxyphenyl)-5-(3-(4-(2-ethyltetrazol-5-yl)phenyloxy)propyl)-Δ²-isoxazoline

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