N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

Base Information

• Chemical Name: N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide
• CAS No.: 680229-44-1
• Molecular Formula: C₂₅H₂₉F₂N₃O₃S
• Molecular Weight: 489.586

Synonyms:N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

Chemical Property of N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

Chemical Property:

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Technology Process of N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

There total 2 articles about N₂-[(3,5-difluorophenyl)acetyl]-N₁-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-[(6,7-cis)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide (680231-26-9) + 3,5-difluorophenyl acetic acid (105184-38-1) → N2-[(3,5-difluorophenyl)acetyl]-N1-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide (680229-44-1) + N2-[(3,5-difluorophenyl)acetyl]-N1-[(6S,7S)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

N2-[tert-butoxycarbonyl]-N1-[(6,7-cis)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide (680231-25-8) → N2-[(3,5-difluorophenyl)acetyl]-N1-[(6R,7R)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide (680229-44-1) + N2-[(3,5-difluorophenyl)acetyl]-N1-[(6S,7S)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 12 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

N₁-[(6,7-cis)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

3,5-difluorophenyl acetic acid

N₂-[tert-butoxycarbonyl]-N₁-[(6,7-cis)-5-oxo-7-phenyl-1,4-thiazepan-6-yl]-L-leucinamide

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